STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES III . T~E EFFECT OF SEN UPON THE INJ~rRy PRODVCING FACTORS OF THE PHENOMENON OF LOCAL SKIN REACTIVITY BY GREGORY SHWARTZMAN, M.D

In previous communications (1-8) there was described a phenomenon of local skin reactivity to culture filtrates of bacillus typhosus and other microorgamsms. The reactivity was induced by the injection of a filtrate into the skin of a rabbit. If 24 hours later an intravenous injection of the same filtrate was given to the rabbit, there appeared an extremely severe hemorrhagic necrosis at the site of the previous injection. The factors determining the local skin reactivity were termed "skin preparatory factors" and those responsible for the local injury following the intravenous injection were called "reacting factors." Features characteristic of this phenomenon as well as certain properties of the skin preparatory factors were described. One of these properties was the specific neutralizability by immune sera of the skin preparatory factors (2, 3). The object of the work reported in this paper was to determine the effect of sera upon the Bacillus typhosus reacting factors.